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Growth Performance in Weaned Piglets
Release date:2017-03-11 09:15    Author:admin    Click: 
Effect of low-molecular-weight (LMW) chitosan on Growth Performance, Intestinal Tract Health and Anti-oxidant in Weaned Piglets
Carried out by Prof. Chuntian Zheng’s group
 Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture
Abstract:This experiment was conducted to investigate the effects of LMW chitosan (KR901) on growth performance,antioxidant status and intestinal tract health and test whether we can replace antibiotic and ZnO with LMW chitosan in weaned piglets. A total of 100 male weaned piglets (Duroc×Landrace×Large White) were randomly assigned to one of five dietary treatments. Each treatment consisted of five pens with four pigs per pen. The five treatments were as follows: 1) control group, piglets were fed with basal diet; 2) tested group I, 300mg/kg 10% aureomycin, 60mg/kg polymyxin E sulfate and 3000mg/kg ZnO was added in basal diet; 3) tested group II, basal diet was used together with 150mg/kg 10% aureomycin, 30mg/kg polymyxin E sulfate, 1500mg/kg ZnO and 50mg/kg LMW chitosan, 4) tested group III, piglets were treated with basal diet, 1500 mg/kg ZnO and 50 mg/kg LMW chitosan, 5) tested group IV, only 50 mg/kg LMW chitosan was added in basal diet. Feed and water were provided and ad libitum over the 28-d experimental period.
Results showed that: 1) Compared with the control group, the average daily gain (ADG) and average daily feed intake (ADFI) in the tested group II and III was significantly increased (P<0.05) during the period of 14-28d and 1-28d, and the diarrhea rate and faces grade was dramatically decreased (P<0.05) in the tested group II. During the period of 14-28d, ADG and ADFI in tested group IV was significantly higher than that in the control group (P<0.05). 2) The length of small intestine of the piglets in tested group III and tested group IV was much longer than that of the control group (P<0.05, P<0.05). While compared with the control group, the pH of cecum significantly decreased in the tested group II (P<0.05). 3) In the tested group III, the activity of maltase and lactase of jejunum mucosa was significantly enhanced compared with the control group (P<0.05). 4) Compared with the control group, the mRNA expression level of ZO-1 jejunum tight junction protein was significantly improved in the tested group III (P<0.05) and the mRNA expression level of Occludin was also increased (P=0.52). 5) The expression of TNF-α in jejunum in the tested group I, II and IV was reduced than that in the control group (P<0.05); jejunum IL-10 expression in the texted group II, III was much higher than the control group (P<0.05); compared with the control group, the mRNA expression level of jejunum TGF-β in the tested group III and jejunum MUC-2 in the tested group IV were both significantly increased (P<0.05,  P<0.05). 6) Compared with the control group, the activity of CAT in tested group II, the activity of TAOC in tested group II and III was significantly increased (P<0.05, P<0.05); While, no vitally effect of Chito-oligosaccharide was found on the activity of GSH-Px, MDA, SOD.
In conclusion, using LMW chitosan to replace half of antibiotic and ZnO can significantly improve the growth performance, intestinal tract health and oxidation of weaned piglets. ADG and ADFI were significantly increased when replaced the antibiotic with Chito-oligosaccharide, while no positive effect on diarrhea rate.

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